Package: esDesign 1.0.3

esDesign: Adaptive Enrichment Designs with Sample Size Re-Estimation

Software of 'esDesign' is developed to implement the adaptive enrichment designs with sample size re-estimation presented in Lin et al. (2021) <doi:10.1016/j.cct.2020.106216>. In details, three-proposed trial designs are provided, including the AED1-SSR (or ES1-SSR), AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition, this package also contains several widely used adaptive designs, such as the Marker Sequential Test (MaST) design proposed Freidlin et al. (2014) <doi:10.1177/1740774513503739>, the adaptive enrichment designs without early stopping (AED or ES), the sample size re-estimation procedure (SSR) based on the conditional power proposed by Proschan and Hunsberger (1995), and some useful functions. In details, we can calculate the futility and/or efficacy stopping boundaries, the sample size required, calibrate the value of the threshold of the difference between subgroup-specific test statistics, conduct the simulation studies in AED, SSR, AED1-SSR, AED2-SSR and AED3-SSR.

Authors:Zhao Yang, Ruitao Lin, Guosheng Yin and Ying Yuan

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esDesign.pdf |esDesign.html✨
esDesign/json (API)
NEWS

# Install 'esDesign' in R:
install.packages('esDesign', repos = c('https://yangzhao98.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

On CRAN:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

19 exports 0.00 score 0 dependencies 19 scripts 238 downloads

Last updated 3 years agofrom:9df37a781b. Checks:OK: 7. Indexed: yes.

TargetResultDate
Doc / VignettesOKSep 14 2024
R-4.5-winOKSep 14 2024
R-4.5-linuxOKSep 14 2024
R-4.4-winOKSep 14 2024
R-4.4-macOKSep 14 2024
R-4.3-winOKSep 14 2024
R-4.3-macOKSep 14 2024

Exports:AED.boundaryAED.simAED1_SSR.boundaryAED1_SSR.CPAED1_SSR.N2AED1_SSR.simAED2_SSR.boundaryAED2_SSR.CPAED2_SSR.simAED3_SSR.boundaryAED3_SSR.CPAED3_SSR.simMaST.simSD.simSigPsSize.normSSR.boundarySSR.CPSSR.sim

Dependencies:

Readme and manuals

Help Manual

Help pageTopics
Calculate the critical value used at the final analysis in AEDAED.boundary
Conduct the simulation studies of the Adaptive Enrichment Design without early stopping boundaryAED.sim
Calculate the critical value used at the final analysis of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation ProcedureAED1_SSR.boundary
Calculate the conditional power of the Adaptive Enrichment Design with (Strategy 1) Sample Size Re-estimation ProcedureAED1_SSR.CP
Calculate the sample size required at the second stage of the adaptive enrichment design (Strategy1) with Sample Size Re-estimation ProcedureAED1_SSR.N2
Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation ProcedureAED1_SSR.sim
Calculate the futility and efficacy stopping boundaries of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation ProcedureAED2_SSR.boundary
Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation ProcedureAED2_SSR.CP
Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation ProcedureAED2_SSR.sim
Calculate the futility and efficacy stopping boundaries in Adaptive enrichment design (Strategy 3) with Sample Size Re-estimation Procedure for the continuous endpointAED3_SSR.boundary
Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation ProcedureAED3_SSR.CP
Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure based on Futility and Efficacy Stopping Boundaries for the continuous endpointAED3_SSR.sim
Conduct the simulation studies of the Marker Sequential Test designMaST.sim
Conduct the simulation studies of the standard designSD.sim
Commonly used alpha-spending functionsSigP
Sample size calculation for the standard design with continuous endpointsSize.norm
Calculate the futility and efficacy stopping boundaries for Sample Size Re-estimation Procedure based on the conditional error functionSSR.boundary
Calculate the N2 and the critical value C in Sample Size Re-estimation ProcedureSSR.CP
Conduct the simulation studies using SSRSSR.sim