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  "Package": "esDesign",
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  "Title": "Adaptive Enrichment Designs with Sample Size Re-Estimation",
  "Version": "1.0.3",
  "Date": "2021-07-13",
  "Author": "Zhao Yang, Ruitao Lin, Guosheng Yin and Ying Yuan",
  "Maintainer": "Zhao Yang <yangz98@connect.hku.hk>",
  "Description": "Software of 'esDesign' is developed to implement the\nadaptive enrichment designs with sample size re-estimation\npresented in Lin et al. (2021) <doi:\n10.1016/j.cct.2020.106216>. In details, three-proposed trial\ndesigns are provided, including the AED1-SSR (or ES1-SSR),\nAED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition,\nthis package also contains several widely used adaptive\ndesigns, such as the Marker Sequential Test (MaST) design\nproposed Freidlin et al. (2014) <doi:10.1177/1740774513503739>,\nthe adaptive enrichment designs without early stopping (AED or\nES), the sample size re-estimation procedure (SSR) based on the\nconditional power proposed by Proschan and Hunsberger (1995),\nand some useful functions. In details, we can calculate the\nfutility and/or efficacy stopping boundaries, the sample size\nrequired, calibrate the value of the threshold of the\ndifference between subgroup-specific test statistics, conduct\nthe simulation studies in AED, SSR, AED1-SSR, AED2-SSR and\nAED3-SSR.",
  "License": "GPL-2",
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  "Date/Publication": "2021-07-13 04:50:02 UTC",
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    "AED.sim",
    "AED1_SSR.boundary",
    "AED1_SSR.CP",
    "AED1_SSR.N2",
    "AED1_SSR.sim",
    "AED2_SSR.boundary",
    "AED2_SSR.CP",
    "AED2_SSR.sim",
    "AED3_SSR.boundary",
    "AED3_SSR.CP",
    "AED3_SSR.sim",
    "MaST.sim",
    "SD.sim",
    "SigP",
    "sSize.norm",
    "SSR.boundary",
    "SSR.CP",
    "SSR.sim"
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    {
      "page": "AED.boundary",
      "title": "Calculate the critical value used at the final analysis in AED",
      "topics": [
        "AED.boundary"
      ]
    },
    {
      "page": "AED.sim",
      "title": "Conduct the simulation studies of the Adaptive Enrichment Design without early stopping boundary",
      "topics": [
        "AED.sim"
      ]
    },
    {
      "page": "AED1_SSR.boundary",
      "title": "Calculate the critical value used at the final analysis of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure",
      "topics": [
        "AED1_SSR.boundary"
      ]
    },
    {
      "page": "AED1_SSR.CP",
      "title": "Calculate the conditional power of the Adaptive Enrichment Design with (Strategy 1) Sample Size Re-estimation Procedure",
      "topics": [
        "AED1_SSR.CP"
      ]
    },
    {
      "page": "AED1_SSR.N2",
      "title": "Calculate the sample size required at the second stage of the adaptive enrichment design (Strategy1) with Sample Size Re-estimation Procedure",
      "topics": [
        "AED1_SSR.N2"
      ]
    },
    {
      "page": "AED1_SSR.sim",
      "title": "Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure",
      "topics": [
        "AED1_SSR.sim"
      ]
    },
    {
      "page": "AED2_SSR.boundary",
      "title": "Calculate the futility and efficacy stopping boundaries of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure",
      "topics": [
        "AED2_SSR.boundary"
      ]
    },
    {
      "page": "AED2_SSR.CP",
      "title": "Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure",
      "topics": [
        "AED2_SSR.CP"
      ]
    },
    {
      "page": "AED2_SSR.sim",
      "title": "Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure",
      "topics": [
        "AED2_SSR.sim"
      ]
    },
    {
      "page": "AED3_SSR.boundary",
      "title": "Calculate the futility and efficacy stopping boundaries in Adaptive enrichment design (Strategy 3) with Sample Size Re-estimation Procedure for the continuous endpoint",
      "topics": [
        "AED3_SSR.boundary"
      ]
    },
    {
      "page": "AED3_SSR.CP",
      "title": "Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure",
      "topics": [
        "AED3_SSR.CP"
      ]
    },
    {
      "page": "AED3_SSR.sim",
      "title": "Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure based on Futility and Efficacy Stopping Boundaries for the continuous endpoint",
      "topics": [
        "AED3_SSR.sim"
      ]
    },
    {
      "page": "MaST.sim",
      "title": "Conduct the simulation studies of the Marker Sequential Test design",
      "topics": [
        "MaST.sim"
      ]
    },
    {
      "page": "SD.sim",
      "title": "Conduct the simulation studies of the standard design",
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      ]
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    {
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      "title": "Commonly used alpha-spending functions",
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      ]
    },
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      "title": "Sample size calculation for the standard design with continuous endpoint",
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      "title": "Calculate the futility and efficacy stopping boundaries for Sample Size Re-estimation Procedure based on the conditional error function",
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      "title": "Calculate the N2 and the critical value C in Sample Size Re-estimation Procedure",
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      ]
    },
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      "title": "Conduct the simulation studies using SSR",
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