{ "_id": "6a1eb6bbb25058d4daade398", "Package": "esDesign", "Type": "Package", "Title": "Adaptive Enrichment Designs with Sample Size Re-Estimation", "Version": "1.0.3", "Date": "2021-07-13", "Author": "Zhao Yang, Ruitao Lin, Guosheng Yin and Ying Yuan", "Maintainer": "Zhao Yang ", "Description": "Software of 'esDesign' is developed to implement the\nadaptive enrichment designs with sample size re-estimation\npresented in Lin et al. (2021) . In details, three-proposed trial\ndesigns are provided, including the AED1-SSR (or ES1-SSR),\nAED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition,\nthis package also contains several widely used adaptive\ndesigns, such as the Marker Sequential Test (MaST) design\nproposed Freidlin et al. (2014) ,\nthe adaptive enrichment designs without early stopping (AED or\nES), the sample size re-estimation procedure (SSR) based on the\nconditional power proposed by Proschan and Hunsberger (1995),\nand some useful functions. In details, we can calculate the\nfutility and/or efficacy stopping boundaries, the sample size\nrequired, calibrate the value of the threshold of the\ndifference between subgroup-specific test statistics, conduct\nthe simulation studies in AED, SSR, AED1-SSR, AED2-SSR and\nAED3-SSR.", "License": "GPL-2", "Encoding": "UTF-8", "RoxygenNote": "7.1.1", "NeedsCompilation": "no", "Packaged": { "Date": "2026-06-02 10:44:56 UTC", "User": "root" }, "Repository": "https://yangzhao98.r-universe.dev", "Date/Publication": "2021-07-13 04:50:02 UTC", "RemoteUrl": "https://github.com/cran/esDesign", "RemoteRef": "HEAD", "RemoteSha": "9df37a781bc9bc1e1e29ac9b70ded5ea6d417c2d", "MD5sum": "3ab808addbfd87957f674504d8670963", "_user": "yangzhao98", "_type": "src", "_file": "esDesign_1.0.3.tar.gz", "_fileid": "49fee3e70489ef812c1e3f605c86976c917a0cd235c92775a0043fd0840a7257", "_filesize": 185911, "_sha256": "49fee3e70489ef812c1e3f605c86976c917a0cd235c92775a0043fd0840a7257", "_created": "2026-06-02T10:44:56.000Z", "_published": "2026-06-02T10:55:55.477Z", "_distro": "noble", "_jobs": [ { "job": 79053407984, "time": 115, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7355597281" }, { "job": 79053408025, "time": 108, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7355594551" }, { "job": 79053407969, "time": 153, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "7355756370" }, { "job": 79053407951, "time": 164, "config": "macos-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "7355749223" }, { "job": 79052882306, "time": 192, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7355556591" }, { "job": 79053407926, "time": 90, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7355587946" }, { "job": 79053408003, "time": 69, "config": "windows-devel", "r": "4.7.0", "check": "OK", "artifact": "7355581203" }, { "job": 79053407997, "time": 79, "config": "windows-oldrel", "r": "4.5.3", "check": "OK", "artifact": "7355585349" }, { "job": 79053407983, "time": 71, "config": "windows-release", "r": "4.6.0", "check": "OK", "artifact": "7355582060" } ], "_buildurl": "https://github.com/r-universe/yangzhao98/actions/runs/26814532296", "_status": "success", "_host": "GitHub-Actions", "_upstream": "https://github.com/cran/esDesign", "_commit": { "id": "9df37a781bc9bc1e1e29ac9b70ded5ea6d417c2d", "author": "Zhao Yang ", "committer": "cran-robot ", "message": "version 1.0.3\n", "time": 1626151802 }, "_maintainer": { "name": "Zhao Yang", "email": "yangz98@connect.hku.hk", "login": "yangzhao98", "description": "PhD", "uuid": 29568039 }, "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.2.0", "role": "Depends" }, { "package": "stats", "role": "Imports" }, { "package": "knitr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" } ], "_owner": "cran", "_selfowned": true, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 0, "_contributors": [ { "user": "yangzhao98", "count": 3, "uuid": 29568039 } ], "_userbio": { "uuid": 29568039, "type": "user", "name": "DemoYang", "description": "PhD" }, "_downloads": { "count": 177, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/esDesign" }, "_searchresults": 19, "_rbuild": "4.6.0", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/esDesign.html", "extra/NEWS.html", "extra/NEWS.txt", "manual.pdf" ], "_realowner": "yangzhao98", "_cranurl": false, "_releases": [ { "version": "1.0.0", "date": "2018-08-10" }, { "version": "1.0.2", "date": "2018-11-23" }, { "version": "1.0.3", "date": "2021-07-13" } ], "_exports": [ "AED.boundary", "AED.sim", "AED1_SSR.boundary", "AED1_SSR.CP", "AED1_SSR.N2", "AED1_SSR.sim", "AED2_SSR.boundary", "AED2_SSR.CP", "AED2_SSR.sim", "AED3_SSR.boundary", "AED3_SSR.CP", "AED3_SSR.sim", "MaST.sim", "SD.sim", "SigP", "sSize.norm", "SSR.boundary", "SSR.CP", "SSR.sim" ], "_help": [ { "page": "AED.boundary", "title": "Calculate the critical value used at the final analysis in AED", "topics": [ "AED.boundary" ] }, { "page": "AED.sim", "title": "Conduct the simulation studies of the Adaptive Enrichment Design without early stopping boundary", "topics": [ "AED.sim" ] }, { "page": "AED1_SSR.boundary", "title": "Calculate the critical value used at the final analysis of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure", "topics": [ "AED1_SSR.boundary" ] }, { "page": "AED1_SSR.CP", "title": "Calculate the conditional power of the Adaptive Enrichment Design with (Strategy 1) Sample Size Re-estimation Procedure", "topics": [ "AED1_SSR.CP" ] }, { "page": "AED1_SSR.N2", "title": "Calculate the sample size required at the second stage of the adaptive enrichment design (Strategy1) with Sample Size Re-estimation Procedure", "topics": [ "AED1_SSR.N2" ] }, { "page": "AED1_SSR.sim", "title": "Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure", "topics": [ "AED1_SSR.sim" ] }, { "page": "AED2_SSR.boundary", "title": "Calculate the futility and efficacy stopping boundaries of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure", "topics": [ "AED2_SSR.boundary" ] }, { "page": "AED2_SSR.CP", "title": "Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure", "topics": [ "AED2_SSR.CP" ] }, { "page": "AED2_SSR.sim", "title": "Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure", "topics": [ "AED2_SSR.sim" ] }, { "page": "AED3_SSR.boundary", "title": "Calculate the futility and efficacy stopping boundaries in Adaptive enrichment design (Strategy 3) with Sample Size Re-estimation Procedure for the continuous endpoint", "topics": [ "AED3_SSR.boundary" ] }, { "page": "AED3_SSR.CP", "title": "Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure", "topics": [ "AED3_SSR.CP" ] }, { "page": "AED3_SSR.sim", "title": "Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure based on Futility and Efficacy Stopping Boundaries for the continuous endpoint", "topics": [ "AED3_SSR.sim" ] }, { "page": "MaST.sim", "title": "Conduct the simulation studies of the Marker Sequential Test design", "topics": [ "MaST.sim" ] }, { "page": "SD.sim", "title": "Conduct the simulation studies of the standard design", "topics": [ "SD.sim" ] }, { "page": "SigP", "title": "Commonly used alpha-spending functions", "topics": [ "SigP" ] }, { "page": "sSize.norm", "title": "Sample size calculation for the standard design with continuous endpoint", "topics": [ "sSize.norm" ] }, { "page": "SSR.boundary", "title": "Calculate the futility and efficacy stopping boundaries for Sample Size Re-estimation Procedure based on the conditional error function", "topics": [ "SSR.boundary" ] }, { "page": "SSR.CP", "title": "Calculate the N2 and the critical value C in Sample Size Re-estimation Procedure", "topics": [ "SSR.CP" ] }, { "page": "SSR.sim", "title": "Conduct the simulation studies using SSR", "topics": [ "SSR.sim" ] } ], "_rundeps": [], "_score": 1.2787536009528289, "_indexed": true, "_nocasepkg": "esdesign", "_universes": [ "yangzhao98" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "1.0.3", "date": "2026-06-02T10:46:58.000Z", "distro": "noble", "commit": "9df37a781bc9bc1e1e29ac9b70ded5ea6d417c2d", "fileid": "d277d535e41b0e65bc35f15009b396dd7ef780f6f286c0cb497581d3692dce86", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/yangzhao98/actions/runs/26814532296" }, { "r": "4.6.0", "os": "linux", "version": "1.0.3", "date": "2026-06-02T10:46:51.000Z", 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