Package: esDesign
Type: Package
Title: Adaptive Enrichment Designs with Sample Size Re-Estimation
Version: 1.0.3
Date: 2021-07-13
Author: Zhao Yang, Ruitao Lin, Guosheng Yin and Ying Yuan
Maintainer: Zhao Yang <yangz98@connect.hku.hk>
Description: Software of 'esDesign' is developed to implement the
        adaptive enrichment designs with sample size re-estimation
        presented in Lin et al. (2021) <doi:
        10.1016/j.cct.2020.106216>. In details, three-proposed trial
        designs are provided, including the AED1-SSR (or ES1-SSR),
        AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition,
        this package also contains several widely used adaptive
        designs, such as the Marker Sequential Test (MaST) design
        proposed Freidlin et al. (2014) <doi:10.1177/1740774513503739>,
        the adaptive enrichment designs without early stopping (AED or
        ES), the sample size re-estimation procedure (SSR) based on the
        conditional power proposed by Proschan and Hunsberger (1995),
        and some useful functions. In details, we can calculate the
        futility and/or efficacy stopping boundaries, the sample size
        required, calibrate the value of the threshold of the
        difference between subgroup-specific test statistics, conduct
        the simulation studies in AED, SSR, AED1-SSR, AED2-SSR and
        AED3-SSR.
Depends: R (>= 3.2.0)
Imports: stats
License: GPL-2
Encoding: UTF-8
RoxygenNote: 7.1.1
Suggests: knitr, rmarkdown
NeedsCompilation: no
Packaged: 2026-09-30 08:38:58 UTC; root
Repository: https://yangzhao98.r-universe.dev
Date/Publication: 2021-07-13 04:50:02 UTC
RemoteUrl: https://github.com/cran/esDesign
RemoteRef: HEAD
RemoteSha: 9df37a781bc9bc1e1e29ac9b70ded5ea6d417c2d